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Procaspase-3 activator 1541B
CAS No. 1170689-68-5
Procaspase-3 activator 1541B( Compound 1541B )
Catalog No. M10573 CAS No. 1170689-68-5
Procaspase-3 activator 1541B is a specific, small molecule activator of procaspases-3 with EC50 of 1.3 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameProcaspase-3 activator 1541B
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NoteResearch use only, not for human use.
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Brief DescriptionProcaspase-3 activator 1541B is a specific, small molecule activator of procaspases-3 with EC50 of 1.3 uM.
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DescriptionProcaspase-3 activator 1541B is a specific, small molecule activator of procaspases-3 with EC50 of 1.3 uM; shows no activition activity for procaspases-6; shows considerable synergy in activating procaspase-3 in vitro combined with PAC-1, stimulates rapid and dramatic maturation of procaspase-3 in multiple cancer cell lines; effectively reduces tumor burden in a murine lymphoma model combined with PAC-1, but not treated alone.
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In Vitro——
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In Vivo——
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SynonymsCompound 1541B
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PathwayApoptosis
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TargetCaspase
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RecptorCaspase
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Research Area——
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Indication——
Chemical Information
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CAS Number1170689-68-5
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Formula Weight397.39
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Molecular FormulaC23H15N3O4
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(C(C1=O)=CC2=C(O1)C(O)=CC=C2)NC3=CC=CC(C4=CN5C=CC=CC5=N4)=C3
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Chemical Name8-hydroxy-N-(3-(imidazo[1,2-a]pyridin-2-yl)phenyl)-2-oxo-2H-chromene-3-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wolan DW, et al. Science. 2009 Nov 6;326(5954):853-8.
2. Botham RC, et al. J Am Chem Soc. 2014 Jan 29;136(4):1312-9.
3. Julien O, et al. Nat Chem Biol. 2014 Nov;10(11):969-76.
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